Borrelidin is a nitrile-containing 18-membered macrolide antibiotic produced by Streptomyces rochei and related species. It functions as a highly selective inhibitor of threonyl-tRNA synthetase (ThrRS) in both prokaryotic and eukaryotic systems, thereby disrupting protein synthesis. In addition to its broad-spectrum antimicrobial activity, borrelidin exhibits potent antiangiogenic effects (IC₅₀ ≈ 0.8 nM), induces apoptosis in endothelial cells, and shows antimalarial and anticancer potential. Its unique structure and multifunctional bioactivity make it a valuable tool in antibiotic research, angiogenesis studies, and drug discovery.
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*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Borrelidin Specifications
| Production strain | Streptomyces parvulus |
| Formula | C₂₈H₄₃NO₆ |
| Purity | ≥98% |
| Solubility | Soluble in methanol, chloroform, and DMSO |
| Storage Temperature | - |
| Shipping Temperature | ambient |
| SMILES | O=C1C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)/C(C#N)=C\C=C\C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])O1 |
| CAS Number | 7184-60-3 |
| Synonyms | (1R)-2R-[7-cyano-8R,16S-dihydroxy-9S,11R,13S,15S-tetramethyl-18-oxooxacyclooctadeca-4E,6Z-dien-2S-yl]-cyclopentanecarboxylic acid;NSC216128;treponemycin |
- Woolard, J., Vousden, W., Moss, S. J., Krishnakumar, A., Gammons, M. V., Nowak, D. G., Dixon, N., Micklefield, J., Spannhoff, A., Bedford, M. T., Gregory, M. A., Martin, C. J., Leadlay, P. F., Zhang, M. Q., Harper, S. J., Bates, D. O., & Wilkinson, B. (2011). Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical science, 2011(2), 273–278. https://doi.org/10.1039/C0SC00297F
- Kawamura, T., Liu, D., Towle, M. J., Kageyama, R., Tsukahara, N., Wakabayashi, T., & Littlefield, B. A. (2003). Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. The Journal of antibiotics, 56(8), 709–715. https://doi.org/10.7164/antibiotics.56.709
- Otoguro, K., Ui, H., Ishiyama, A., Kobayashi, M., Togashi, H., Takahashi, Y., Masuma, R., Tanaka, H., Tomoda, H., Yamada, H., & Omura, S. (2003). In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. The Journal of antibiotics, 56(8), 727–729. https://doi.org/10.7164/antibiotics.56.727
- Tsuchiya, E., Yukawa, M., Miyakawa, T., Kimura, K. I., & Takahashi, H. (2001). Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. The Journal of antibiotics, 54(1), 84–90. https://doi.org/10.7164/antibiotics.54.84
- Wilkinson, B., Gregory, M. A., Moss, S. J., Carletti, I., Sheridan, R. M., Kaja, A., Ward, M., Olano, C., Mendez, C., Salas, J. A., Leadlay, P. F., vanGinckel, R., & Zhang, M. Q. (2006). Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorganic & medicinal chemistry letters, 16(22), 5814–5817. https://doi.org/10.1016/j.bmcl.2006.08.073
- Mirando, A. C., Fang, P., Williams, T. F., Baldor, L. C., Howe, A. K., Ebert, A. M., Wilkinson, B., Lounsbury, K. M., Guo, M., & Francklyn, C. S. (2015). Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Scientific reports, 5, 13160. https://doi.org/10.1038/srep13160
Our Borrelidin Prices
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity | Cost |
|---|---|
| 100 µg | $85 |
| 1 mg | $181 |
| 5 mg | $440 |
| 10 mg | $566 |
| >10 mg | Request a Quote |
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