Macbecin BC265 is a more potent analogue of macbecin I, and is a macrocyclic ansamycin antibiotic that acts as a potent HSP90 inhibitor, disrupting the function of this molecular chaperone by binding to its ATP-binding site. This inhibition leads to the degradation of several oncogenic client proteins, contributing to its strong antitumor and antimicrobial activity. Originally isolated from actinomycetes, Macbecin I has shown efficacy against various cancer models and microbial organisms.
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*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Macbecin BC265 Specifications
| Formula | C₂₈H₄₂N₂O₆ |
| Purity | ~95% |
| CAS Number | - |
| Solubility | Soluble in DMSO; water (partly) |
| Storage Temperature | -20°C |
| Shipping Temperature | ambient |
| Molecular Weight | 502.64 |
| SMILES | CCCc1cc(O)cc(NC(=O)/C(C)=C/CC[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@H](CC)OC)c1 |
| Synonyms | - |
- Gregory, M.A., Moss, S.J., and Wilkinson, B. (2014). BC265: A Nonquinone Ansamycin Hsp90 Inhibitor Developed Using Biosynthetic Medicinal Chemistry. In Natural Products (eds A. Osbourn, R.J. Goss and G.T. Carter). https://doi.org/10.1002/9781118794623.ch26
- Martin, C. J., Gaisser, S., Challis, I. R., Carletti, I., Wilkinson, B., Gregory, M., Prodromou, C., Roe, S. M., Pearl, L. H., Boyd, S. M., & Zhang, M. Q. (2008). Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of medicinal chemistry, 51(9), 2853–2857. https://doi.org/10.1021/jm701558c
- Deshpande RP, Wu K, Wu SY, Tyagi A, Smith EC, Kim JW, Watabe K. MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy. EMBO Mol Med. 2025 Apr;17(4):797-822. doi: 10.1038/s44321-025-00213-7
- Zhang, M. Q., Gaisser, S., Nur-E-Alam, M., Sheehan, L. S., Vousden, W. A., Gaitatzis, N., Peck, G., Coates, N. J., Moss, S. J., Radzom, M., Foster, T. A., Sheridan, R. M., Gregory, M. A., Roe, S. M., Prodromou, C., Pearl, L., Boyd, S. M., Wilkinson, B., & Martin, C. J. (2008). Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Journal of medicinal chemistry, 51(18), 5494–5497. https://doi.org/10.1021/jm8006068
Our Macbecin BC265 Prices
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity (mg) | Cost per mg |
|---|---|
| Any | Request a Quote |
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