Macbecin I is a macrocyclic ansamycin antibiotic that acts as a potent HSP90 inhibitor, disrupting the function of this molecular chaperone by binding to its ATP-binding site. This inhibition leads to the degradation of several oncogenic client proteins, contributing to its strong antitumor and antimicrobial activity. Originally isolated from actinomycetes, Macbecin I has shown efficacy against various cancer models and microbial organisms.
✉ This email address is being protected from spambots. You need JavaScript enabled to view it.
*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Macbecin I Specifications
| Formula | C₃₀H₄₂N₂O₈ |
| Purity | ≥98% |
| CAS Number | 73341-72-7 |
| Solubility | Soluble in DMSO; water (partly) |
| Storage Temperature | -20°C |
| Shipping Temperature | ambient |
| Molecular Weight | 558.67 g/mol |
| SMILES | O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
| Synonyms | (15R)-6,17-Didemethoxy-15-methoxy-6 -methyl-11-O-methyl-geldanamycin |
- Zhang, M. Q., Gaisser, S., Nur-E-Alam, M., Sheehan, L. S., Vousden, W. A., Gaitatzis, N., Peck, G., Coates, N. J., Moss, S. J., Radzom, M., Foster, T. A., Sheridan, R. M., Gregory, M. A., Roe, S. M., Prodromou, C., Pearl, L., Boyd, S. M., Wilkinson, B., & Martin, C. J. (2008). Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Journal of medicinal chemistry, 51(18), 5494–5497. https://doi.org/10.1021/jm8006068
- Martin, C. J., Gaisser, S., Challis, I. R., Carletti, I., Wilkinson, B., Gregory, M., Prodromou, C., Roe, S. M., Pearl, L. H., Boyd, S. M., & Zhang, M. Q. (2008). Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of medicinal chemistry, 51(9), 2853–2857. https://doi.org/10.1021/jm701558c
- Deshpande RP, Wu K, Wu SY, Tyagi A, Smith EC, Kim JW, Watabe K. MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy. EMBO Mol Med. 2025 Apr;17(4):797-822. doi: 10.1038/s44321-025-00213-7
Our Macbecin I Prices
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity | Cost |
|---|---|
| 1 mg | $176 |
| 10 mg | $824 |
| >10 mg | Request a Quote |
Isomerase
We are a synthetic biology company and innovation partner helping partners to use microbes to make anything from therapeutics to enzymes, agricultural and consumer products, sustainably, cost-effectively, and at scale.
Interested in finding out more? Contact us today.