Microbial Strains

We are a leader in contract bacterial and fungal research, focusing on prokaryotic and eukaryotic microbial strains. For partners, we effectively use microorganisms to sustainably and cost-effectively generate new products at scale. 

How can Isomerase help your microbial strain research?

Our background in culturing actinobacteria facilitated the creation of our culture collection, which we have continued to expand to a collection that now has > 20,000 strains, including:

• >7000 actinomycete strains
• >1500 biotransformation strains
• >2500 extremophile strains

Our services include sourcing rare strains from public strain collections or patents, confirming their viability and ability to produce compounds of interest, whilst developing a process for target product production. 

Furthermore, in our commitment to ongoing growth and innovation, we have created IsoChassis^TM, a proprietary platform for microbial expression. Our engineered microbial hosts are designed to meet diverse industrial needs, achieving high yields at scale. Our portfolio features Escherichia coli, Pichia pastoris, and Bacillus subtilis.

These strains and resources can serve as the foundation for a new project, providing a solid starting point for further development.

Examples of microbial strains we regularly work with and their applications: 

	Rich sources of small molecules and biocatalytic enzymes:	Easy to bioengineer and culture enabling efficient peptide and protein production:
Prokaryotic	Streptomyces Bacillus Corynebacterium Pseudomonas Mycobacterium Myxobacterium and many others.	Escherichia
Eukaryotic	Basidiomycetes Aspergillus Trichoderma Candida Yarrowia and many others.	Saccharomyces Pichia

How can Isomerase help develop a microbial strain?

At Isomerase, we specialize in strain development services. We have developed a wide range of technologies to generate and optimize microbial strains: 

• Strain engineering is used to increase the productivity of a strain or remove unwanted contaminants or side products. 
• Pathway engineering focuses on optimizing metabolic pathways to improve the yield of a desired product. 
• Bioinformatics-guided discovery involves using genomic data to identify genes or clusters that produce a target compound, aiding the location of strains and the process development to deliver target products.
• Synthetic biology service is centered on developing and improving tools to engineer existing and rare strains. 
• Secondary metabolite engineering creates or edits biosynthetic gene clusters to generate natural products and their analogs. 
• Bioprocess development applies our in-house high cell-density fermentation strategies to achieve high metabolite and biomass yields. 

Contact us to discuss the specific requirements of your project. Whether you need to source a rare strain or help with the development of a difficult strain, we are here to help.