Pladienolide A is a naturally occurring 12-membered macrolide isolated from Streptomyces platensis, notable for its potent antitumor activity. It functions by selectively binding to the SF3b subunit of the spliceosome, thereby inhibiting pre-mRNA splicing—a critical step in gene expression. This disruption leads to cell cycle arrest and apoptosis in cancer cells. Pladienolide A and its analogs (e.g., E7107) exhibit low nanomolar IC₅₀ values against a wide range of human cancer cell lines and have demonstrated tumor regression in xenograft models, positioning them as promising leads in spliceosome-targeted cancer therapeutics.
✉ This email address is being protected from spambots. You need JavaScript enabled to view it.
*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Pladienolide A Specifications
| Formula | C₂₈H₄₆O₇ |
| Purity | ≥98% |
| CAS Number | 445493-22-1 |
| Solubility | Soluble in DMSO |
| Storage Temperature | -20°C |
| Shipping Temperature | Ambient |
| Molecular Weight | 494.7 g/mol |
| SMILES | C/C([C@@H]1[C@H](/C=C/[C@@H]([C@](O)(CC[C@H](CC(O1)=O)O)C)O)C)=C\C=C\[C@@H](C)C[C@@H]2[C@@](O2)([H])[C@H](C)[C@@H](O)CC |
| Synonym | (9E)-4,7,8-trihydroxy-12-[(2E,4E)-7-[3-(3-hydroxypentan-2-yl)oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-7,11-dimethyl-1-oxacyclododec-9-en-2-one |
- Sakai, T., Sameshima, T., Matsufuji, M., Kawamura, N., Dobashi, K., & Mizui, Y. (2004). Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. The Journal of antibiotics, 57(3), 173–179. https://doi.org/10.7164/antibiotics.57.173
Our Pladienolide A Prices
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity (mg) | Cost per mg |
|---|---|
| Any | Request a Quote |
Isomerase
We are a synthetic biology company and innovation partner helping partners to use microbes to make anything from therapeutics to enzymes, agricultural and consumer products, sustainably, cost-effectively, and at scale.
Interested in finding out more? Contact us today.