Pladienolide B is a natural macrolide compound derived from Streptomyces platensis, known for its potent inhibition of the spliceosome, specifically the SF3B1 subunit of the splicing factor 3B complex. By disrupting pre-mRNA splicing, it interferes with gene expression, leading to cell cycle arrest and apoptosis in cancer cells. Its strong antitumor activity makes it a valuable tool in cancer research and RNA biology.
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*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Pladienolide B Specifications
| Production strain | Streptomyces platensis |
| Formula | C₃₀H₄₈O₈ |
| Purity | ≥98% |
| CAS Number | 445493-23-2 |
| Solubility | Soluble in DMSO and MeOH |
| Storage Temperature | -20°C |
| Shipping Temperature | ambient |
| Molecular Weight | 536.7 g/mol |
| SMILES | O=C1O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1 |
| Synonyms | [(4E)-7,10-dihydroxy-2-[(2E,4E)-7-[3-(3-hydroxypentan-2-yl)oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-3,7-dimethyl-12-oxo-1-oxacyclododec-4-en-6-yl] acetate |
- Lee, S. C., & Abdel-Wahab, O. (2016). Therapeutic targeting of splicing in cancer. Nature medicine, 22(9), 976–986. https://doi.org/10.1038/nm.4165
- Li, S., Yang, M., Shen, H., Ding, L., Lyu, X., Lin, K., Ong, J., & Du, P. (2024). Capturing totipotency in human cells through spliceosomal repression. Cell, 187(13), 3284–3302.e23. https://doi.org/10.1016/j.cell.2024.05.010
- Sato, M., Muguruma, N., Nakagawa, T., Okamoto, K., Kimura, T., Kitamura, S., Yano, H., Sannomiya, K., Goji, T., Miyamoto, H., Okahisa, T., Mikasa, H., Wada, S., Iwata, M., & Takayama, T. (2014). High antitumor activity of pladienolide B and its derivative in gastric cancer. Cancer science, 105(1), 110–116. https://doi.org/10.1111/cas.12317
Our Pladienolide B Prices
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity | Cost |
|---|---|
| 100 µg | $135 |
| 500 µg | $261 |
| 1 mg | $691 |
| 5 mg | $1,728 |
| 10 mg | $5,014 |
| >10 mg | Request a Quote |
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