Soraphen A is a natural macrolide that acts as a potent inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme in fatty acid biosynthesis.
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*FOR RESEARCH USE ONLY. Not for human or veterinary use. This product is intended exclusively for laboratory research and must not be used in diagnostic or therapeutic applications.
Soraphen A Specifications
| Formula | C₂₉H₄₄O₈ |
| Purity | ≥98% |
| CAS Number | 122547-72-2 |
| Solubility | - |
| Storage Temperature | -20°C |
| Shipping Temperature | ambient |
| Molecular Weight | 520.7 g/mol |
| SMILES | C[C@H]1C=C[C@H]([C@H](CCCC[C@@H](C2=CC=CC=C2)OC(=O)[C@@H](C)[C@@]3([C@@H]([C@H]([C@H](C)[C@H]1O3)O)OC)O)OC)OC |
| Synonym | (1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-1,17-dihydroxy-10,11,18-trimethoxy-2,14,16-trimethyl-5-phenyl-4,19-dioxabicyclo[13.3.1]nonadec-12-en-3-one |
- Koutsoudakis, G., Romero-Brey, I., Berger, C., Pérez-Vilaró, G., Monteiro Perin, P., Vondran, F. W., Kalesse, M., Harmrolfs, K., Müller, R., Martinez, J. P., Pietschmann, T., Bartenschlager, R., Brönstrup, M., Meyerhans, A., & Díez, J. (2015). Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. Journal of hepatology, 63(4), 813–821. https://doi.org/10.1016/j.jhep.2015.06.002
- Cordonier, E. L., Jarecke, S. K., Hollinger, F. E., & Zempleni, J. (2016). Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells. European journal of pharmacology, 780, 202–208. https://doi.org/10.1016/j.ejphar.2016.03.052
- Shen, Y., Volrath, S. L., Weatherly, S. C., Elich, T. D., & Tong, L. (2004). A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Molecular cell, 16(6), 881–891. https://doi.org/10.1016/j.molcel.2004.11.034
Need additional documentation? Safety Data Sheet, Certificate of Analysis and batch-specific data are available upon request from our technical support team.
Our Prices for Soraphen A
*For custom handling, including aliquoting or specific packaging formats, please get in touch with our technical support team.| Quantity | Cost |
|---|---|
| 1 mg | $800 |
| 5 mg | $3650 |
| ≥50 mg | Request a Quote |
💡 Bulk Discounts Available: Contact us for custom pricing on orders over 50 mg
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