Isomerase has supported many biotech and pharma companies with drug discovery, development and manufacturing. Examples have included the following:
- Developing and running screening cascades - to discover novel bioengineered drugs in a range of therapeutic areas with partners following supply of a Target Product Profile (TPP)
- Generating and helping scale recombinant lower cost fermentation processes - to generate drug candidates following initial drug discovery and/or clinical development with a candidate made by synthetic chemistry
- Discovering and supporting manufacturing of biocatalytic processes - to replace or support synthetic chemistry routes to candidate drugs
- Accessing microbial natural products - for biological testing following selection by partner using in silico selection or following literature reports of activity
- ADC payloads - generation of novel payloads or for use with Antibody Drug Conjugates (ADCs) and support with manufacturing
- Drug development support - with early-stage analytical method development and characterisation studies (solubility, stability, microsome stability, metabolic fate, internal standard procurement)
- Early-stage formulation studies - (solubility, stability) to enable in vivo assessment
Isomerase is adept at accessing difficult to access chemical space, whether that is a genetically encoded small molecule (e.g. natural product or peptide) or identifying and producing a key biocatalyst to enable small molecule compound supply.