Isomerase were approached by a biotech company looking to generate 100s mg quantities of a therapeutic polyketide macrolide.

• Solution: Targeted rational bioengineering and fermentation improvement

Initial assessment of the literature producing strain (a filamentous actinomycete bacteria) revealed low and inconsistent production (<1mg/L).

USP fermentation development, strain selection and targeted expression of a regulator gene rapidly increased the titre of product to >0.5g/L, sufficient to enable production of the required quantities. Fermentation and isolation was carried out in-house at Isomerase and material supplied of sufficient quantity and quality to enable further development.

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improving the titre of a therapeutic macrolide

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