Our bioinformatics services
Our bioinformatics services can be the focus of an entire project or serve as an enabling tool used across project design and development. In-silico analysis can include genome sequencing and identification of an enzyme or discovery of a biosynthetic gene cluster. Additionally, we have proprietary software, EvoSelect®, for machine-learning guided enzyme engineering and the directed evolution of enzymes.
We use bioinformatics to assess the potential of bacteria and fungi in producing compounds and proteins of interest. Our innovation partners can leverage these capabilities with our own extensive culture collection and public collections. We have worked with partners in the US, Europe, and throughout the world.
Bioinformatics analysis is used alongside our extensive knowledge in working with diverse strains to allow us to engineer analogs, improve processes, and optimise titers. Our bioinformatics services also allow us to select ‘best-fit’ heterologous expression and production strains.
What is bioinformatics?
Bioinformatics is the science of analysing large amounts of biological information via the application of computer science and information technology. It is particularly relevant in the fields of genomics and molecular biology.
We assess large amounts of genomic data (such as the genome of an organism that produces a valuable enzyme) and help find the gene sequence coding for the enzyme of interest. Bioinformatics is used to help design constructs to express this gene in a heterologous host, such as E. coli or Pichia.
How can our bioinformatics services support your projects?
Bioinformatics is a complex and rapidly evolving field. Our bioinformaticians use, generate, and adapt software to help solve complex biological problems. We have conducted a wide range of bioinformatics projects on behalf of partners.
Projects can be standalone or provide support for other existing or new projects.
Examples include:
- Genome analysis: Our bioinformatics services include next-generation sequence assembly, annotation, and analysis of prokaryotic and eukaryotic genomes for secondary metabolite production.
- Genomics, proteomics, and transcriptomics bioinformatics: Genome analysis of bacterial and fungal strains to identify enzymes responsible for particular biocatalytic activities.
- Ligand binding modeling: Molecular modeling to predict the binding of a new ligand into an existing ligand-bound crystal structure.
- Bioinformatics for genetic design: Bioinformatics services can support the design of expression cassettes for genes from vastly different genera.
- Bioinformatics services consultancy: We also run standalone consultancy projects as a bioinformatics services provider.
Why might Isomerase's bioinformatics services be right for my project?
We not only have expertise in bioinformatics but also biosynthesis, enzyme engineering, genome analysis, and synthetic biology. We take on complex bioinformatics projects and run them on behalf of partners in an open and collaborative way.
This enables us to support partner projects with specific bioinformatics services as required, without them needing to hire staff, or software and wet lab access themselves.