At Isomerase, we offer a comprehensive suite of microbial expression hosts through our proprietary IsoChassis® platform, enabling industrial-scale production of:
- Enzymes and proteins
- Peptides
- Natural product analogues
- Novel small molecules
Scalable Bacterial, Yeast & Fungal Hosts for Industrial Bioproduction
Our bacterial, yeast and fungal hosts can be used in a wide range of bioproduction applications in US-based industries such as pharma, biotech, agritech, food, consumer goods and functional materials. IsoChassis® hosts are fully scalable and optimized for cost-effective biomanufacturing, with proven success in both lab and industrial settings across the United States.
Our Core Bioproduction Platforms
Yeast and fungi for complex, high quality and controlled production:
Pichia pastoris (Komagataella phafii)
- GRAS
- Methanol and methanol-free induction
- Antibiotic-free production system
- Patented episomal plasmid methods
- Stable chromosomal integration
- High cell density fermentation in defined media
Saccharomyces cerevisiae (Brewer's yeast)
- GRAS
- Tolerates acidic conditions
- Simplified purification
Bacteria for simple, rapid and cost-effective production:
Escherichia coli
- Toxic and low yielding proteins
- Low temperature recombinant production
- Protease-deficient strains
- Periplasmic secretion
- Metabolic and chromosomal engineering
- Drop-in high cell density fermentation methods
Bacillus subtilis
- GRAS
- Integrative and replicative vectors
- Sporulation mutants
- Constitutive and inducible promoters
- In-house CRISPR method
We are continuously expanding our portfolio by investing in internal research to enhance our strain offerings, ensuring we stay at the forefront of enzyme production technology.
Advantages of our microbial expression hosts
Each of our core microbial production hosts has it's own unique advantages depending on industry, regulatory and process specific requirements. Without this detailed understanding of each host, bioproduction will be suboptimal which has drastic commercial impacts when scaling. To ensure we develop our customers an industrially scalable solution, we have scientists with years of experience working on our platform hosts.
Overall the benefits of IsoChassis® are:
- Versatile and customisable: our team brings decades of experience working with a variety of industrial microbial hosts, meaning we can confidently select the correct one for your proceess.
- Evaluation and optimization: a variety of system component combinations can be evaluated, ensuring optimal productivity.
- Ownership: no downstream fees or royalties for strains made for your target product.
- Integrated solution: part of the IsoZym® platform enabling production from sequence to scale.
Strain & Pathway Optimization Capabilities
To maximize performance of our hosts, we offer advanced genome and pathway engineering including:
- Proprietary CRISPR-Cas-like genome editing tools
- Metabolic pathway optimization
- Custom vector and promoter systems
Typical goals include:
- Enhanced flux toward target molecules
- Reduced byproduct formation
- Improved product yields
- Expanded biosynthetic capabilities
Engineering is provided as an enabling service, fully integrated with IsoChassis® hosts or as a standalone offering for your preferred hosts.
Additional Microbial Expression Host Portfolio
Beyond our core IsoChassis® hosts, we actively develop and optimize production strains from a broad range of bacterial, yeast and fungal taxa, including:
- Streptomyces
- Corynebacterium
- Pseudomonas
- Mycobacterium
- Aspergillus
- Trichoderma
- Basidiomycetes and others.
Our proprietary strain collection enable rapid development of bespoke microbial hosts tailored to your product and market needs.
Contact Us
If you'd like to learn more about the capabilities of our IsoChassis® hosts email us at