Accelerating the Development of Enzymes, Bioprocesses and Engineered Microbial Systems
Isomerase partners with biotechnology, pharmaceutical, industrial and consumer product companies to develop innovative biological solutions that can be translated into scalable commercial processes. Through two complementary technology platforms, IsoZym® and IsoStream®, we help organizations solve challenges spanning enzyme discovery, biocatalysis, microbial strain engineering and biomanufacturing.
Our multidisciplinary teams combine expertise in synthetic biology, microbiology, protein engineering, fermentation, metabolic engineering, analytical sciences and process development to move projects from concept through to manufacturing readiness.
Whether your objective is to identify a novel enzyme, optimize a biocatalytic process, engineer a microbial production strain or develop a fermentation-based manufacturing route, Isomerase provides integrated R&D capabilities designed to accelerate development and reduce technical risk.
Choose the Right Platform for Your Program
| IsoZym® | IsoStream® |
|---|---|
| Enzyme discovery & engineering | Microbial strain engineering |
| Biocatalysis development | Natural product development |
| Protein expression | Fermentation & scale-up |
| Reaction optimisation | Pathway engineering |
| Fermentation & scale-up | Strain improvement |
IsoZym®
Enzyme Discovery, Protein Engineering and Biocatalysis Development
IsoZym® provides a comprehensive framework for the discovery, optimization and implementation of enzymes across a wide range of industrial applications. The platform supports organizations seeking new enzyme solutions, improved biocatalyst performance or scalable manufacturing processes.
By integrating computational biology, assay development, high-throughput screening, protein engineering and fermentation expertise, IsoZym® enables rapid progression from enzyme concept to commercial implementation.
Applications
- Discovery of novel enzymes for challenging chemical transformations
- Zero-shot protein engineering using EvoSelect® technology
- Identification of alternative enzymes to support freedom-to-operate strategies
- Expression and production using multiple microbial hosts through IsoChassis®
- Biocatalytic process development and optimization
- Enzyme cascade design and reaction engineering
- Fermentation and scale-up development
- Manufacturing and technology transfer support
Companies use IsoZym® to improve catalyst performance, reduce process costs, enhance sustainability and enable the manufacture of products that are difficult to produce using traditional chemistry. Industries served include:
- Pharmaceuticals
- Industrial biotechnology
- Agricultural technology
- Food and beverage ingredients
- Specialty chemicals
- Sustainable manufacturing
Learn how IsoZym® can accelerate enzyme development and commercial deployment.
Learn more about the IsoZym® platform
IsoStream®
Microbial Strain Engineering and Natural Product Commercialization
IsoStream® supports the development of microbial production platforms for natural products, specialty ingredients and bio-based chemicals. The platform combines strain engineering, pathway optimization, fermentation development and downstream processing expertise to create scalable biological manufacturing solutions.
From discovery-stage research through to process optimization and technology transfer, IsoStream® helps organizations establish commercially viable production routes for high-value molecules.
Key Capabilities
- Microbial strain engineering and optimization
- Metabolic pathway design and construction
- Natural product discovery and development
- Genome mining for novel biosynthetic pathways
- Fermentation process development
- Scale-up and manufacturing support
- Downstream processing development
- Technology transfer and commercialization readiness
IsoStream® provides access to a proprietary microbial collection containing more than 20,000 strains alongside external biological resources. These assets support the discovery and development of novel metabolites, bioactive compounds and microbial production pathways.
Explore how IsoStream® can help transform microbial innovation into scalable manufacturing processes.
Learn more about the IsoStream® platform
Why Work with Isomerase?
Organizations choose Isomerase because of our ability to combine deep scientific expertise with commercially focused project execution. Our team has extensive experience supporting U.S. partners, working with both early-stage innovators and established multinational companies to advance complex R&D programmes from concept through to scale-up and manufacturing readiness.
What Sets Us Apart
- Integrated Technical Expertise: Our teams bring together specialists in enzyme engineering, synthetic biology, microbiology, fermentation, analytics and bioprocess development to address complex technical challenges.
- Commercial Perspective: Projects are designed around measurable outcomes, clearly defined milestones and informed decision-making to support efficient development pathways.
- Flexible Partnership Models: We work with clients through a range of engagement structures and we do not require downstream royalty obligations, enabling greater flexibility in commercialization strategies.
- Manufacturing-Focused Development: Our goal is not simply to generate scientific results, but to develop robust, scalable technologies that can transition successfully into manufacturing environments.
Contact our experts to discuss your project and identify the right development pathway with IsoZym® or IsoStream®.