We are a leader in contract bacterial and fungal research, focusing on microbial strain development of both prokaryotes and eukaryotes.. For partners, we effectively use microorganisms to sustainably and cost-effectively generate new products at scale.
How can Isomerase help your microbial strain research?
Our background in culturing actinobacteria facilitated the creation of our culture collection, which we have continued to expand to a collection that now has > 20,000 strains, including:
- >7000 actinomycete strains
- >1500 biotransformation strains
- >2500 extremophile strains
Our services include sourcing rare strains from public strain collections or patents, confirming their viability and ability to produce compounds of interest, whilst developing a process for target product production.
Furthermore, in our commitment to ongoing growth and innovation, we have created IsoChassisTM, a proprietary platform for microbial expression. Our engineered microbial hosts are designed to meet diverse industrial needs, achieving high yields at scale. Our portfolio features Escherichia coli, Pichia pastoris, and Bacillus subtilis.These strains and resources can serve as the foundation for a new project, providing a solid starting point for further development.
Examples of microbial strains we regularly work with and their applications:
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Sources of small molecules and biocatalytic enzymes: |
Easy to bioengineer and culture, enabling efficient peptide and protein production: |
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Prokaryotic |
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Eukaryotic |
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How can Isomerase help you develop a microbial strain?
We specialise in microbial strain development and have developed a wide range of techniques to generate and optimise these, including:
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- Strain engineering is used to enhance the productivity of a particular strain or remove unwanted by-products.
- Pathway engineering focuses on optimising metabolic pathways to improve the titre of a metabolite.
Our synthetic biology services are centred on developing and improving tools to engineer common and rare strains.
- Bioinformatics-guided discovery utilises genomic data to identify genes or clusters responsible for the production of a target compound, facilitating the location of strains and the process development to deliver target products.
- Secondary metabolite engineering is used to create or edit biosynthetic gene clusters to generate natural products and their analogues.
- Bioprocess development applies our in-house high cell-density fermentation strategies to achieve high metabolite and biomass yields.
Contact us to discuss the specific requirements of your project. As a strain development CRO, we are dedicated to providing solutions for your research in strain bioengineering, bioinformatics, and Chemistry.