Microbial natural products remain a vital source of active compounds for human therapeutics, veterinary medicine, and agriculture. Their importance in small molecule drug development cannot be overstated. Since 1981, 49.2 % of all approved drugs have been derived from, mimicked, or inspired by natural products[1].
We initiate and manage microbial natural product discovery
At Isomerase, we focus on microbial natural product development. This includes discovering, isolating, and optimizing these compounds for our partners. With expertise in bioinformatics, biosynthetic pathway manipulation, and strain bioengineering, we speed up the development of next-generation bioactive compounds.
Your innovation partner in microbial natural products
We manage end-to-end natural product discovery projects, from genomic analysis to compound isolation.
We engineer microbial strains to:
- Enable the biosynthesis of analogues.
- Boost production of target compounds.
- Eliminate competing metabolic pathways.
- Achieve commercially viable titers.
Our proprietary strain collection, which includes over 20,000 microbial entities, provides a unique advantage in natural product discovery. Coupled with access to public and patent strain libraries, we enable the discovery of novel compounds tailored to your application.
Extensive experience across compound classes
Our technologies enable the discovery and development of natural products from a wide array of classes, including:
- Ribosomal Peptides
- Non-Ribosomal Peptides
- Proteins
- Polyketides
- Lipopeptides
- Steroids and sterols
- Terpenes or terpenoids
- Glycosylated products
Proven expertise for 20+ years
With over two decades of experience across Isomerase, Biotica Technology, and the University of Cambridge, we offer scalable solutions for industry in bioengineering and natural product R&D.
Microbial Strain Capabilities:
- We work with both wild-type and genetically modified strains.
- Expertise in unicellular & filamentous fungi, gram-positive and gram-negative bacteria.
Pathway Engineering & Fermentation:
- We optimize biosynthetic pathways in industrially proven strains.
- We ferment, isolate, and purify natural products from milligram to kilogram scale.
Chemistry Services:
- In-house team for isolation, purification, and analytical characterization.
- Semi-synthesis of natural products.
- Validated compound supply, matched to client specifications.
Microbial natural product case studies.
We support clients across a variety of industries. Our example projects include:
- Research and discovery of natural product producers in strain and patent collections.
- Bioinformatic mining of genomic data to discover novel biosynthetic gene clusters.
- Sequencing and analysis of genomes for biosynthetic potential.
- Literature-based or in silico discovery of novel natural product analogues
- Synthetic biology and heterologous expression using in-house, commercially viable IsoChassisTM strains.
Partner with Isomerase.
Whether you’re starting a new program or scaling up an existing one, Isomerase brings unmatched expertise in microbial biotechnology, synthetic biology, and natural product discovery. See here for our publications on natural products.
Contact us to find out how we can support your R&D goals.
Examples of Microbial Natural Products
|
Microbial Natural Product |
Literature application and target / natural product mechanism of action |
| A-10255-B | |
| A-3802-IV | |
| A40926 | Antibiotic |
| A47934 | Antibiotic |
| A-500359 | Antibiotic |
| A-503083 | Inhibitor Of Bacterial Translocase I |
| A54145 | Antibiotic |
| A-74528 | 2',5'-Oligoadenylate Phosphodiesterase Inhibitor |
| Aborycin | Antibiotic |
| Aburatubolactam A | Inhibitor Of Superoxide Anion Generation |
| Abyssomicin I | Antibacterial Through Inhibiting The Enzyme Pabb (4-Amino-4-Deoxychorismate Synthase) |
| Acarbose | Antidiabetic |
| Acetomycin | Antibiotic |
| Acidocin | |
| Acinetobactin | Siderophore |
| Aclarubicin | Topoisomerase I/II Inhibitor |
| Actagardine | Antibacterial |
| Acticin 3147 | Antibiotic |
| Actinomycin | Transcription Inhibitor |
| Actinopyrone A | Infectious Disease (Helicobacter) |
| Actinorhodin | Antibacterial |
| Actinotetraose Hexatiglate (Tigloside) | |
| Aculeximycin | Antibiotic (Gram Positive And Negative Bacteria), Larvicidal |
| Adriamycin | Dna Intercalating Agent, Dna Topoisomerase 2-Alpha Inhibitor (Cytotoxic) |
| Aerucyclamide A | |
| Aeruginosamide | |
| Aeruginoside | Thrombin Inhibitor |
| Aeruginosin | Serine Protease Inhibitor |
| Aesturamide | |
| Aflastatin A | |
| Aflatoxin | Toxin |
| Agardhipeptin A | |
| Ah 758 | Antibiotic (Active Againts Herpes Virus) |
| Ajudazol | Antifungal, Mitochondrial Respiraotry Chain Inhibitor |
| Ala(0)-Actagardine | |
| Albicidin | DNA Gyrase Inhibitor |
| Albocycline | Prolyl Endopeptidase (Infectious Disase (Antiviral, Insecticidal), Inhibitor Of Nicotinate Biosynthesis |
| Albomycin | Antibacterial |
| Alchivemycin A | Antibacterial, Antitumour |
| Aldgamycin | Antimicrobial |
| Altamycin | PDGFR Inhibitor |
| Alteramide A | Antifungal, Microtubule Binding |
| Althiomycin | Broad-Spectrum Antibiotic |
| Ambruticin | Activating Fungal High Osmolarity Glycerol (HOG) Pathway; Putative Proteasome Inhibitor |
| Amethobottromycin-B | |
| Ammocidin | Apopotosis Induction In Ras-Dependent Cells |
| Amphomycin | Antibacterial |
| Amphotericin | Sterols (Antifungal) |
| Amycomycin | Antibiotic |
| Amylocyclicin | |
| Amythiamicin A | |
| Anabaenopeptilide | Serine Protease Inhibitors |
| Anabaenopeptin | Inhibitor Of Carboxypeptidase TAFIa. |
| Anachelin | Antibiotic |
| Anacyclamide | |
| Anantin | Antagonist Of Atrial Natriuretic Factor |
| Anatoxin | |
| Angiolam A | |
| Angolamycin | Antibiotic |
| Angolosaminyl Tylactone | Bacterial Ribosome |
| Angucycline | Cytostatic (Oncology) |
| Anguibactin | Siderophore |
| Anguinomycin A | CRM1, Exportin1 |
| Ansamitocin P3 | Tubulin (Oncology) |
| Ansatrienin | Antibiotic And Antifungal |
| Ansatrienin A | GRP78 (Oncology) |
| Antascomicin B | FKBP inhibitor |
| Anthramycin | Antitumour And Antibiotic |
| Antibiotic 3874H1 | Antibiotic |
| Antibiotic 67-121A | Antibiotic |
| Antibiotic A 10255E | |
| Antibiotic A 10255J | |
| Antibiotic A 82548A | Antibiotic |
| Antibiotic A 83016F | Putative Binder Of EF-Tu |
| Antibiotic A130C | Antibiotic |
| Antibiotic A-23187 | Inhibits Mitochondrial ATPase Activity |
| Antibiotic A59770A | Antibiotic |
| Antibiotic A73A | Antibiotic |
| Antibiotic Ab 023A | Antibiotic |
| Antibiotic Ac 326 Alpha | Antibiotic |
| Antibiotic An 023B | Antibiotic |
| Antibiotic Cp 91243 | Antibiotic |
| Antibiotic Fr 252921 | Antibiotic |
| Antibiotic Fr 252922 | Antibiotic |
| Antibiotic Fr 256523 | Antibiotic |
| Antibiotic Ge 37468A | |
| Antibiotic HA-1-92 | Antibiotic |
| Antibiotic Ib 96212 | Antibiotic |
| Antibiotic Ikd 8344 | Antibiotic |
| Antibiotic K41 | Antibiotic |
| Antibiotic L 681,217 | EF-Tu Inhibitor |
| Antibiotic Ll Z1640-2 | TAK1 |
| Antibiotic RK-682 | Inhibits Protein Tyrosine Phosphatases And Heparanase |
| Antibiotic S 541 | Antibiotic |
| Antibiotic S 632C | Antibiotic |
| Antibiotic Sch 18640 | |
| Antibiotic Sch 38518 | Antibiotic |
| Antibiotic Ss49 | Antibiotic |
| Antibiotic Ta | Inhibits Type II Signal Peptidase |
| Antibiotic TAN 420C | Hsp90 Inhibitor |
| Antibiotic TAN 420E | Hsp90 Inhibitor |
| Antibiotic TP 1161 | |
| Antibiotic TPU-0037-A | Antibiotic |
| Antibiotic TPU-0037-C | Antibiotic |
| Antibiotic U 56407 | Antibiotic |
| Antibiotic Ucf 116A | Ras Farnesyl Tranferase (Oncology) |
| Antibiotic UCN-01 | PKC, CDK2 |
| Antibiotic Uk-1 | Antibiotic |
| Antibiotic Vm 44866 | Antibiotic |
| Antibiotic X 14931A | Antibiotic |
| Antibiotic X 14952B | Inhibitor Of Mitochondrial ATP Synthase Complex |
| Antibiotic X206 | Antibiotic |
| Antimycin | Respiratory Chain Inhibitor |
| Apicidin | HDAC inhibitor |
| Apicularen | V-ATPase (Oncology) |
| Aplysiatoxin | Protein Kinase C Activation |
| Apoptolidin | F0F1-ATPase Inhibition (Oncology) |
| Apramycin | |
| Apratoxin A | Antineoplastic - Arrests Cell Cycle |
| Aranciamycin | Antimicrobial |
| Archazolid | V-ATPase (Oncology) |
| Arimetamycin | Antineoplastic |
| Arthrofactin | Biosurfactant |
| Arthrospiramide A | |
| Ascidiacyclamide | |
| Ascochlorin | MMP-9 Matrix Metalloproteinase-9 Inhibits MEK/ERK Signaling Pathway |
| Ascomycin | Calcineurin Inhibitor |
| Astexin-1 | |
| Asukamycin A1 | Antimicrobial And Potential Antitumor |
| Aurafuron | Cytotoxic |
| Aurantimycin A | Antibacterial And Cytotoxic |
| Aurenin | Antibiotic |
| Aureothin | Oxidoreductase Inhibition. |
| Auricin | Antibiotic |
| Aurodox (Delvomycin, Mocimycin) | EF-Tu Inhibitor (Bacterial Protein Synthesis) |
| Avermectin (Ivermectin, Abamectin) | Glutamate-Gated Chlorine Channel Binder, Insecticide |
| Avermipeptin | |
| Avilamycin | Antibiotic (Poultry Use) |
| Avilamycin A | Inhibits Bacterial Protein Synthesis |
| Axinastatin | |
| Axinellin C | |
| Azalomycin | Antifungal Through Cytosolic Phospholipase A2 |
| Azdimycin | Antibiotic |
| Azinomycin | Antitumor |
| Azithromycin | Antibiotic |
| Azonomycin B | Oncology |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Bacillaene | Gram Negative Antibiotic |
| Bacillibactin | Siderophore |
| Bacillomycin | Antifungal Antibiotic |
| Bacitracin | Topical Antibiotic Against Gram positive Bacteria, Disrupts Cell Synthesis |
| Bacteriocin J46 | |
| Bacteriocin Uberolysin | |
| Bafilomycin | V-ATPase (Oncology) |
| Balhimycin | Antibiotic |
| Banyascyclamide A | |
| Barbamide | Molluscicidal Agent |
| Batumin | Antistaphylococcal |
| BE-14106 | Antifungal, Hes1 Inhibitor |
| Beauvericin | Specific Inhibitor Of Cholesterol Acyltransferase |
| Berninamycin | FoxM1 inhibitor |
| Beta-Rubromycin | HIV-1 Reverse Transcriptase |
| BI-32169 | Antagonist Of Glucagon Receptor |
| Bialaphos | Herbicide |
| Bikaverin | Pigment With Antibiotic Properties |
| Bischloroanthrabenzoxocinone | Type II Fas Inhibitor |
| Bistratamide A | |
| Blasticidin A | Antibiotic |
| Blasticidin S | Disruption Of Ribosomal Activity |
| Bleomycin | Inhibits DNA Synthesis (Oncology) |
| B-Ny266 | |
| Bongkrekic Acid | Adenine Nucleotide Translocase, mPTP |
| Boromycin | Antiviral, Bacteriocidal |
| Borrelidin (Treponemycin) | Spliceosome, tRNA Synthetase (Oncology) |
| Bottromycin | Antibiotic |
| Bovicin Hj50 | |
| Branimycin | Antibiotic |
| Brasinolide A | Plant-Growth Promoting |
| Bryostatin | PKC Pathway (Oncology) |
| Bundlin A | Antimicrobial |
| Burhizin | |
| Butyrivibriocin Ar10 | |
| Butyrivibriocin Or79 | |
| Butyrolactol A | Antifungal |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| C-1027 | Antitumor Antibiotic, Antiangiogenic |
| Caerulomycin | Antibiotic |
| Calcimycin | Calcium Ionophore |
| Calcium Ionophore A23187 | Inhibits Mitochondrial ATPase Activity |
| Calicheamicin | DNA (Oncology) |
| Calphostin C | PKC Inhibitor (Oncology) |
| Calyculin A | Protein Phosphatase 1, Protein Phosphatase 2A |
| Candicidin | Antifungal |
| Capistruin | Rna Polymerase Inhibitor |
| Capreomycin | Antibiotic |
| Carbomycin | Antibacterial |
| Carnocyclin A | |
| Carnolysin A1 | |
| Carriomycin | Antibiotic |
| Catenulipeptin | |
| Cationomycin | Ionophore |
| Caulonodin I | |
| Caulosegnin | |
| CDA (Calcium-Dependent Antibiotic) | Antibiotic |
| Cephalosporin | Antibacterial |
| Cephamycin-C | Antibiotic |
| Cercosporin | Photoactivated Plant Toxin |
| Cerecidin | |
| Cereulide | Toxin |
| Chalcomycin | Protein Synthesis Inhibitor (Antibacterial) |
| Chartreusin | Topoisomerase |
| Chaxapeptin | |
| Chivosazol | Antifungal |
| Chivosazole | Actin (Oncology) |
| Chloramphenicol | Antibiotic |
| Chlorobiocin | Antibacterial |
| Chloroeremomycin (Oritavancin) | Antibacterial, Antitumour |
| Chlorothricin | Grp78 Pathway, Malate Dehydrogenase |
| Chlortetracycline Hcl | Antibacterial - Bacterial Ribosome |
| Chondramide | Oncology (Disrupts Actin Cytoskeleton) |
| Chondrochloren | Antibiotic |
| Chrolactomycin | Antitumor |
| Chromomycin A3 | Sp1 (HIV-1) |
| Chrysomycin A | Topoisomerase |
| Cinnamycin | |
| Circularin A | |
| Citrinin | Carcinogenic Mycotoxin |
| Clarithromycin | Antibiotic |
| Clavulanic Acid | Antibacterial |
| Clethramycin | Antifungal, Inhibitor Of Pollen Tube Growth |
| Cochlioquinone B | CCR5 (HIV-1) Inhibitor Of NADH-Ubiquinone Reductase |
| Coibacin | Antileishmanial |
| Colibactin | Genotoxin |
| Collismycin A | Iron Chelator |
| Comoramide A | |
| Compactin | Cardiovascular Applications |
| Complestatin | C4B,2B Complex and Gp120-CD4 |
| Comx | |
| Concanamycin | V-ATPase (Oncology) |
| Conglobatin | NFAT Pathway (Oncology) |
| Copiamycin | Antifungal |
| Copsomycin | |
| Coronafacic Acid | Phytotoxin |
| Coronatine | Phytotoxin |
| Coumermycin | Antibacterial |
| Cp-60993 | Ionophore |
| Crisamicin A | Antibiotic |
| Crocacin | Electron Transport Inhibitor |
| Crocain | Antibiotic |
| Cryptophycin A | Tubulin (Oncology) |
| Csg104-175L | |
| Curacin | Cytotoxic (Antiproliferative) |
| Curacin A | Cytotoxic (Antiproliferative) |
| Curromycin A | GRP78 |
| Curromycin B | Antiviral (HIV) |
| Curvopeptin | |
| Curvularin | Disrupts Mitotic Spindle (Oncology) |
| Cyanopeptin | |
| Cyanopeptolin | Chymotrypsin Inhibitor |
| Cyanothecamide A | |
| Cyclodidemnamide | |
| Cycloheximide | Interact With Colchicine Binding Sites On Tubulin, Antiproliferative |
| Cyclonellin | |
| Cyclosporin, Cyclosporine A | Immunosuppressant |
| Cyclostreptin | Tubulin (Oncology) |
| Cyclothiazomycin | |
| Cycloxazoline | |
| Cylindrocyclophane | 20S Proteasome |
| Cylindrospermopsin | Protein Synthesis Inhibitor |
| Cymbimicin A | Cyclophilin |
| Cypemycin | Antibiotic |
| Cystobactamids | Topoisomerase Inhibitor |
| Cystomanamide | HIV-1 Inhibition, Antifungal |
| Cystothiazole | Antibiotic |
| Cystothiazolea | Antibiotic |
| Cytolysin LL | |
| Cytolysin LS | |
| Cytotrienin A | Eukaryotic Elongation Factor 1A (eEF1A) |
| Cytovaricin | Antibiotic |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Dalbavancin | Antibacterial |
| Daptomycin | Antibacterial |
| Daunorubicin.Hcl | Antitumor |
| D-Cycloserine | Anti-Tubercular |
| Decatromicin B | Antibiotic |
| Delactonmycin | Antiviral, HIV rev Protein |
| Dendroamide A | |
| Dermostatin | Antibiotic |
| Desertomycin | Antibiotic |
| Desotamide | Bacterial RNA Polymerase |
| Dhanyabadomycin | Antifungal |
| Dianemycin | Antibiotic, Ionophore And Uncoupler |
| Didmolamide | |
| Difficidin | Broad Spectrum Antibiotic |
| Dilactonmycin | HIV rev Inhibitor (Antiviral) |
| Dinactin | T-Cell Proliferation |
| Disorazol | Antifungal |
| Disorazole | Antitumor (Antimitotic) |
| Dolastatin E | |
| Dolastatin I | |
| Doramectin | |
| Dothistromin | Broad-Spectrum Mycotoxin |
| Doxorubicin | Topoisomerase II, Bacterial Ribosome |
| Doxycycline Hycalate | Topoisomerase II, Bacterial Ribosome |
| Dunaimycin C1 | Immunosuppressive |
| Duramycin | Phosphatidylethanolamine Binder |
| Dynemicin | Intercalating Into The Minor Groove Of B-DNA Helix |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Ebelactone | Pancreatic Lipase, Esterase |
| Ebelactone A | Inhibitor Of Extracellular Cathepsin A-Type Enzyme |
| Echinocandin | Antifungal |
| Echinomycin | Blocking The Binding If HIF1Alpha |
| Efrotomycin | Antibiotic |
| Elaiophylin | Inhibitor Of NO Synthesis |
| Elansolid | Activity Against Gram-Positive Bacteria. |
| Elasnin | Elastase Inhibitor |
| Elgicin | |
| Ellaiophylin | NO Synthesis (Immunomodulator, Antihelminthic ) |
| Elloramycin | Antimicrobial |
| Elmycin B | Antibiotic |
| EM574 | Motilin Receptor Agonist |
| Enduracidin | Antibiotic |
| Enduracidin (Enramycin) | Inhibitor Of MurA (Cell Wall Synthesis Inhibitor) |
| Endusamycin | Antibiotic |
| Enniatin | Anti-HIV (Ionophore) |
| Enterobactin | Siderophore |
| Enterocin | Antibiotic |
| Enterocin AS-48 | |
| Enterocin NKR-5-3D | |
| Entianin | |
| Epicidin 280 | |
| Epidermin | |
| Epilancin 15X | |
| Epilancin K7 | |
| Epothilone | Tubulin Stabilization/Dynamics |
| Equisetin | HIV-1 Integrase |
| Erdacin | Antibacterial |
| Ergometrine | Cardiovascular |
| Ergovaline | Toxin |
| Ericin A | |
| Erythreapeptin 7 | |
| Erythromycin | Antibacterial (Bacterial Ribosome) |
| Erythronolide B | Antibiotic |
| Esperamicin | DNA Splicing, Antitumour |
| Etheromycin | Antibiotic |
| Exochelin | Ferric Chelating Substance |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Factumycin | Type III Secretion System Inhibitor |
| FD-594, FD594 | Antitumour |
| FD-891, FD891 | Triggers Caspase-8-Dependent Mitochondrial Release Of Cytochrome C And Subsequent Apoptosis |
| Fengycin | Antifungal |
| Fidaxomicin | Bacterial RNA Polymerase. |
| Filipin | EGF-R Inhibitor |
| Fischerellin | Photosystem-Ii-Inhibiting Allelochemical, Antifungal, Herbicidal |
| Fk228 | HDAC1/HDAC2 Inhibitor |
| FK506, FK-506 (Tacrolimus) | Immunosuppressive, FKBPs, Calcineurin |
| FK520, FK520 | FKBPs, Calcineurin, Ca Stem Cell Inhibitor |
| Flavofungin I | Antifungal |
| Fluviricin | Antiviral |
| Fostriecin | PP2A, Topoisomerase |
| Fr-008 | Antifungal |
| Fr-901451 | |
| Fredericamycin | Pin1 (Oncology) |
| Friulimicin | Antibiotic |
| Fumitremorgin | Tremorogene |
| Fumonisin | Ceramide Synthase Inhibitor |
| Fungichromin (Pentamycin) | Antifungal |
| Fusaricidin | Antibiotic And Antifungal |
| Fusarin | Antimitotic Mycotoxin |
| Fusidic Acid | Antibacterial |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| G-15-I | |
| Gallidermin | |
| Garvicin Ml | |
| Gassericin A | |
| Ge 2270 | |
| Geldanamycin | Oncology Hsp90 |
| Geninthiocin | Inhibits FoxM1 |
| Gentamicin | Antibacterial |
| Geobacillin I | |
| Gephyronic Acid | Antifungal, Inhibitor Of Processing Bodies Assembly |
| Gilvocarcin M | Inhibitor Of Human Topoisomerase II |
| Gliotoxin | Immunosuppressive Virulence Factor Of Aspergillus; Inhibitor Of Farnesyl Transferase |
| Glycocin F | Antimicrobial |
| Glycopeptilide | |
| Goadsporin | Bacterial Hormone |
| Gramicidin | Antibacterial, Uncoupler (Mitochondrial) |
| Granaticin | Inhibition Of Ribosomal RNA Maturation |
| Grisemycin | |
| Griseopeptin | |
| Grisorixin | Ionophore |
| Guadinomine | Anti-Infective Compound |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Haliclonamide A | |
| Haloduracin Hal Alpha | |
| Haloduricin | Antibiotic |
| Halomicin A | Antibiotic |
| Halstoctacosanolide | Antibiotic |
| HC Toxin | Antimitogenic |
| Hectochlorin | Hectochlorin |
| Heinicomycin | |
| Herbimycin | Hsp90. Inhibits Protein Tyrosine Kinase And Angiogensis. |
| Herboxidiene | Sf3B Protein Binder, Spliceosome Inhibitor, Antitumour |
| Heronamide A | |
| Hexacyclinic Acid | |
| Hexamollamide | |
| Hominicin | |
| Homodolastatin 3 | |
| Homooligomycin A | Cytotoxic |
| Hormaomycin | Bacterial Hormone, Narrow-Spectrum Antibiotic. |
| Humidimycin Mdn-0010 | |
| Hydroxyl-Maltophilin | Antifungal |
| Hygrolidin | Crop Protection, Cell Cycle Arrest |
| Hygromycin | Antibacterial |
| Hymeglusin | HMG-CoA Synthase Inhibitor |
| Hymenamide | |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Idanomycin | Antiparasitic, Insecticidal, And Antibacterial |
| Idarubicin | Topoisomerase II, Bacterial Ribosome |
| Ikarugamycin | Inhibits Clathrin-Mediated Endocytosis |
| Indanomycin | Ionophore |
| Indigoidine | Antibiotic, Dye |
| Informatipeptin | |
| Integramycin | HIV-1 Integrase Inhibitor |
| Ionomycin | Induces PKC, Ca Ionophore |
| Iromycin | Selective eNOS Inhibitor |
| Irumamycin | Antifungal |
| IS 83 | |
| Isoapoptolidin | F0F1-ATPase |
| Isoheinicomycin | Angiogenesis And Migration/Metastasis Inhibition |
| Iso-Migrastatin | Antineoplastic |
| Iturin | Pore-Former (Antibacterial) |
| Ivermectin | Nematocidal |
| Jamaicamide A | Neurotoxin |
| Jerangolid | Antifungal |
| Josamycin | Antibacterial (Inhibits Translocation Of Peptidyl tRNA) |
| K252c | Protein Kinase C |
| Kaimonolide B | Herbicide |
| Kamonolide | Plant Growth |
| Kanamycin (Amikacin) | Antibacterial |
| Kanchanamycin | Antibiotic |
| Kawaguchipeptin A | |
| Kazusamycin | Nuclear Export Inhibitor |
| Kedarcidin | DNA (Oncology) |
| Kendomycin | Proteasome Inhibitor |
| Kigamicin C | Blocking Act Pathways |
| Kijanimicin | Grp78 Pathway |
| Kirromycin (Delvomycin, Mocimycin) | Antibiotic EF-Tu |
| Kirrothricin | Antibiotic |
| Kororamide | |
| Kutzneride | Antifungal And Antimicrobial |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| LabA1 | |
| Labilomycin | Antibiotic |
| Labyrinthopeptin | Antiallodynic Activity |
| Lactazole | |
| Lacticin 3147 A1 | |
| Lacticin 481 | |
| Lactimidomycin | Angiogenesis And Migration/Metastasis Inhibition |
| Lactocillin | |
| Lactocin S | |
| Lactocyclicin Q | |
| Lactomycin | Antifungal |
| Lactoquinomycin | AKT/PKB Inhibitor |
| Laidlomycin | Antibiotic, Ionophore |
| Lajollamycin | Antibiotic |
| Lambdamycin | Topoisomerase |
| Langkolide | Phosphodiesterase PDE4 (Antibiotic) |
| Lankacidin | Antitumour, Antimicrobial |
| Lankacyclinol | Antibiotic |
| Lankamycin | Antibacterial |
| Lanthionine Containing Peptide | |
| Lariatin | Anti-Mycobacterial |
| Lariatin A | |
| Lasalocid | Ionophore, Antibiotic / Coccidiostat |
| Lassomycin | |
| Lavendofuseomycin | Antibiotic |
| Legonaridin | |
| Leinamycin | Antitumour, Antibiotic, DNA Synthesis Inhibitor |
| Leiodermatolide | Potent Cytotoxic And Antimitotic |
| Leptomycin | CREM-1/Exportin 1 - Nuclear Protein Transport |
| Leucanicidin | Insecticidal, Potent Nematocidal |
| Leucasandrolide A | Antitumor |
| Leucocyclicin Q | |
| Leucomycin A1 | Animal Health Product (Antimicrobial) |
| Leucomycin V (Kitasamycin) | Antibiotic |
| Leustroducsin A | Inhibits T-Cell Proliferation |
| Leustroducsin B | NF-KB Stimulator |
| Leustroducsin C | Antibacterial, Antitumour, Antifungal |
| Lichenicidin A1 | |
| Lichenysin | Cytotoxic, Antimicrobial, And Hemolytic, Surfactant |
| Lienomycin | Antibiotic |
| Lincomycin (Clindamycin) | Antibacterial |
| Lipiarmycin (Fidaxomycin) | RNA Polymerase Inhibitor, Antibiotic |
| Lipomycin | Potent Gram Positive Antibacterial Activity Without Fungicidal Activity |
| Liposidolide A | Antifungal |
| Liposidomycin | Inhibitor Of Bacterial Peptidoglycan Synthesis |
| Lipstatin (Xenical) | Antiobesity |
| Lissoclinamide 1 | |
| Lonomycin | Ionophore |
| Lovastatin | Cardiovascular Applications |
| Lugdunin | Antibacterial |
| Luisol A | Antibiotic |
| Luteoreticulin | Antibiotic |
| Lydicamycin | Antibiotic |
| Lymphostin | Immunosuppressant |
| Lyngbyatoxin | Blister Agent, Carcinogen, Toxin |
| Lysolipin | Antibacterial, Glycopeptide Synthesis Inhibitor |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Macbecin I | Hsp90 Inhibitor |
| Macedocin | |
| Maclafungin | Antifungal |
| Macrolactin | FabG Inhibitor, Antimicronbial |
| Macrolactin A | Anti-Angiogenic |
| Macrolactin N | Peptide Deformylase Inhibitor |
| Macrolactin S | Fabg Inhibitor, Antibacterial |
| Maduramycin | Ionophore, Anticryptosporidial |
| Maduropeptin | DNA Binder (Oncology) |
| Magnamycin (Carbomycin) | Antibiotic |
| Malolactomycin | MMP-1, MMP-9, Ras Signalling (Oncology) |
| Mannopeptimycins | Antibiotic |
| Manoalide | PLA2 |
| Manumycin | Farnesyltransferase, STAT3, Ras Pathway (Oncology) |
| Manumycin A | Farnesyltransferase (Ras Pathway), STAT3, Telomerase, By Elevating ROS |
| Marcfortine A | Nematocidal Activity |
| Marinostatin | |
| Massetolide | Crop Protection |
| Mathemycin A | Antifungal |
| Mayotamide | |
| Mechercharstatin A | |
| Mechercharstatin B | |
| Medermycin | Inhibitor Of Platelet Aggregation |
| Mediomycin A | Antibiotic |
| Mediomycin B | Antibiotic |
| Megalomycin | Protein Synthesis Inhibitor, Antibiotic |
| Meilingmycin | Anthelmintic |
| Meilingmycin D | Antibiotic |
| Melithiazol | Electron Transport Chain Inhibitor |
| Mensacarcin | Antitumor |
| Mepartricin | Estrogen Reabsorption Inhibitor |
| Meridamycin | FKBPs, Calcineurin, Ca Stem Cell Inhibitor |
| Mersacidin | |
| Methylpendomycin | Antibiotic |
| Methylsulfomycin I | |
| Methylstreptimidone | Oncology, NF-Κb |
| Methymycin | Neutrophil Mediated Inflammation |
| Michiganin | |
| Microbisporicin | |
| Microbisporicin B | |
| Microcin B17 | DNA Gyrase Inhibitor (Antibiotic) |
| Microcin J25 | Integrin Antagonist (Cancer, Multiple Sclerosis, Crohn'S Disease, Psoriasis, Rheumatoid Arthritis And Acute Coronary Syndromes) |
| Microcins B17 | Antibacterial, Gyrase Inhibitor |
| Micrococcin P1 | Prokaryotic 50S Ribosomal Subunit |
| Microcyclamide | Cytotoxic |
| Microcystin | PP1 And PP2A Inhibitor |
| Microginin | Leucin Aminopeptidase Inhibitor |
| Micropeptin | Plasmin And Trypsin Inhibitor |
| Microphycin Al828 | |
| Microviridin A | |
| Midecamycin | 50S Subunit Of Ribosome Inhibitor |
| Migrastatin | Angiogenesis And Migration/Metastasis Inhib. |
| Milbemycin | Cl-Gated Ion Channels |
| Minocycline | NF-Kb, PKC MHCII |
| Mithramycin A | Antitumour c-myc Pathway, Collagen-1 Gene Expression, Activates Fas Death Pathway |
| Mitomycin C | DNA synthesis inhibitor |
| Mj 347 81F4 A | |
| Ml-449 | Antimicrobial, Antifungal |
| Mm47755 | Antibacterial And Antifungal |
| Moenomycin | Antibacterial |
| Mollamide | |
| Monactin | Inhibits T-Cell Proliferation |
| Monazomycin | Antibiotic, Channel Former |
| Monensin | Ionophore, Antibiotic |
| Monensin A | Trans Golgi-Protein Transport Inhib. Ionophoric |
| Monocillin II | Antitumour, Inhibiting MAPK Pathways And CDK2 Phosphorylation |
| Mupirocin | Antibacterial |
| Muscoride A | |
| Mutacin 1140 | |
| Mutacin H-29B | |
| Mutacin I | |
| Mutalomycin | Antibiotic |
| Mycinamycin | Antibiotic |
| Mycobactin | Siderophore |
| Mycochelin A | |
| Mycolactone | Toxin Responsible For Buruli Ulcers |
| Mycophenolic Acid | Immunomodulator |
| Mycosubtilin | Antifungal And Hemolytic |
| Mycotrienol I | |
| Myriocin | Serine Palmitoyltransferase |
| Myxalamid | Inhibit Nadh Oxidation At Complex I |
| Myxalamide | Potent Inhibitor Of Mitochondrial Complex I |
| Myxochromide | Antibacterial |
| Myxothiazol | Respiratory Chain Inhibitor |
| Myxothiazole A | Cytochrome bc1 Inhibitor |
| Myxovirescin A | Type II Signal Peptidase Inhibitor, Antimicrobial |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| N000632 | |
| N000633 | |
| Nai-107 | |
| Nai-112 | |
| Nai-802 | |
| Nairaiamide A | |
| Nanchangmycin | Antiviral Active Against Zika Virus |
| Naphthomycin A | Antineoplastic (DNA And RNA Synthesis Inhibitor) |
| Naphthomycin B | GRP78 |
| Naphtomycin | Antibiotic |
| Naphtopyrone | Glucosidase Inhibitor |
| Napsamycin | Inhibitors Of Bacterial Translocase I |
| Napthocycliquinone | |
| Napthomycin | Antibacterial |
| Napyradiomycin | Inhibitor Of Mitochondrial Complexes I And II |
| Narasin | Coccidiostat (Antibiotic) |
| Narbomycin | Protein Synthesis Inhibitor, Antibiotic |
| Nargenicin | DneE Targetting Antimicrobial, Nuclear Factor-Kappa Beta, Antibiotic |
| Nargenicin A1 | Transcription Factor Nuclear Factor |
| Nargenicin B1 | NF-KB Inhibitor |
| Natamycin (Pimaricin) | |
| Nemadectin | Antihelmintic |
| Neoantimycin | GRP78 Transcription Inhibitor |
| Neoaureothin | Anti-HIV And Antifungal Activity |
| Neocarzinostatin | DNA (Oncology) |
| Neomethymycin | Antibiotic |
| Neomycin | Antibacterial |
| Neooxaloamycin | |
| Netropsin | Antitumor |
| Nfat-133 | Inhibit The Activation Of The Transcription Factor - NFAT In Jurkat Cells |
| Niddamycin | Binds To 50S Ribosomal Subunits To Inhibit Protein Synthesis |
| Nigericin | Ionophore, Stem Cells, Antibiotic |
| Nikkomycin | Antifungal |
| Niphimycin | Antifungal |
| Nisin | Food Preservative |
| Nocardamine | Tetracycline Efflux Pump Inhibitor |
| Nocardithiocin | |
| Nocathiacin | |
| Nodularin | Cyanotoxin |
| Nodusmicin | Antibiotic |
| Nogalamycin | Topoisomerase I |
| Nonactin | Ionophore Antibiotic |
| Nosiheptide | Prokaryotic 50S Ribosomal Subunit |
| Nostocyclamide | |
| Nostocyclamide M | |
| Nostocyclopeptide | Inhibits Hepatocyte Drug Transporters OATP1B3 And OATP1B1 |
| Nostopeptilide | |
| Notonesomycin | Antibiotic |
| Novobiocin | GyrB |
| Np-001015 | |
| Np-006904 | |
| Np-006905 | |
| Np-006975 | |
| Np-009140 | |
| Np-011522 | |
| Nukacin Isk-1 | |
| Nystatin | Forms Membrane Pores |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Oasomycin A | Antibiotic |
| Obscurolide A1 | Phosphodiesterase Inhibitor |
| Okilactomycin | Antibiotic |
| Oleandomycin | Inhibitor Of Protein Biosynthesis |
| Oleficin | Ionophore |
| Oligomycin | V-ATPase (Oncology) |
| Oligomycin A | F0F1-ATPase |
| Oligomycin B | F0F1-ATPase |
| Omomycin | Antibiotic |
| Onnamide | Cytotoxic, Antiviral |
| Oocydin | Anti-Oomycete (Crop Protection) |
| Ophiobolin A | Inhibits Ca2+/Calmodulin-Dependent Phosphodiesterase |
| Orevactaene | HIV-1 Rev Inhibitor |
| Orgamide | |
| Oscillacyclin | |
| Ossamycin ( Antibiotic B 61,893) | Antitumor |
| Ostreogrycin A | Inhibits Peptidyl tRNA |
| Oxazolomycin | Antiviral |
| Oxyhygrolidin | V-ATPase (Oncology) |
| Oxytetracycline | Antibacterial |
| Pacidamycin | Translocase MraY, Blocks Bacterial Cell Wall Assembly |
| Pacidamycin 3 | Antibiotic |
| Paclitaxel | Tubulin |
| Paebacillibactin | Siderophore |
| Paenibacillin | |
| Paenibactin | Siderophore |
| Paenicidin A | |
| Paraherquamide A | Anthelmintic (Inhibits Motility) |
| Partricin | Antifungal |
| Patellamide A | Antineoplastic |
| Patellin 1 | |
| Pederin | Toxin, Insect Secretion, Putative Translation Inhibitor |
| Pellasoren | Antitumor |
| Penicillin | Antibacterial |
| PEP-5 | |
| Perimycin | Antibiotic |
| Pestalotin | Gibberellin Synergist And Plant Growth Stimulator |
| Phakellistatin 1 | |
| Phenelfamycin | Antibiotic |
| Philipimycin | |
| Phillipin (Filipin) | Antifungal |
| Phoslactomycin | Protein Phosphatase Iia Inhibitor |
| Phoslactomycin A | PP2A |
| Phosphinothricin | Broad-Spectrum Herbicide |
| Phosphomycin | Antibacterial |
| Picromycin | Neutrophil Mediated Inflammation |
| Piericidin | NADPH-Ubiquinone Oxidoreductase (Oncology) |
| Piericidin (Shaoguamycin) | NADPH-Ubiquinone Oxidoreductase (Oncology) |
| Pikromycin | Prolyl Endopeptidase Inhibitor |
| Pimaricin (Natamycin) | Ergosterol Binder: Transport Inhibitor; Antifungal |
| Pinensin | |
| Piricyclamide 7005 E2 | |
| Piricyclamide 7005 E3 | |
| Piricyclamide 7005 E4 | |
| Pironetin | Actin (Oncology) |
| Pladienolide | Spliceosome - SF3B |
| Planktocyclin | |
| Planosporicin | |
| Plantaricin C | |
| PlantaricinW Alpha | |
| Plantazolicin | Antibiotic, Target Unknown |
| Plantazolicin A | |
| Platenomycin B2 | Antibiotic |
| Platensimycin | FabF Inhibitor |
| Pleuromutalin | Antibacterial |
| Pneumocandin | Antifungal |
| Polyketomycin | Antibacterial, Antitumor, And Antimalarial |
| Polymyxin (Colistin) | Antibiotic (Disrupts Membrane) |
| Polyoxin | Antifungal |
| Polytheonamide A | Cytotoxic |
| Pradimicin | Terminal D-Mannosides Of The Cell Wall And Cell Wall Disruption |
| Pradimycin A | Anti-HIV |
| Pre-Borrelidin | Threonyl tRNA-Synthetase |
| Prelissoclinamide 2 | |
| Pre-Macbecin | Hsp90 Inhibitor |
| Prenylagaramide A | |
| Prenylgaramide | |
| Prepatellamide A | |
| PRE-T | |
| Preulicyclamide | |
| Preulithiacyclamide | |
| Primycin A1 | Antibiotic |
| Pristinamycin | Antibiotic |
| Prochlorosin | |
| Prodigiosin | BCL2 |
| Promoinducin | |
| Promothiocin | |
| Propeptin | Prolyl Endopeptidase Inhibitor |
| Pseudomonic Acid | Isoleucyl tRNA Synthetase |
| Psymberin | Cytotoxin, Antitumour |
| Putisolvin II | Inhibits Biofilm Formation |
| Pyochelin | Siderophore |
| Pyoluteorin | Antifungal |
| Pyoverdin | Cytotoxic |
| Pyoverdine | Siderophore |
| Pyrrolomycin | |
| Pyrrolosporin A | Antitumour Antibiotic |
| Quartromicin | HIV-1 Inhibitor |
| Quinaldopeptin | Antimicrobial And Cytotoxic, DNA Intercalator |
| Quinomycin A | HIF-1 |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| R1128 | Estrogen-Receptor Antagonists |
| Radamycin | |
| Radicicol | Hsp90; Protein Tyrosine Kinase (Oncology) |
| Ramoplanin | Antibacterial |
| Raocyclamide A | |
| Raocyclamide B | |
| Rapamycin (Sirolimus) | mTOR, FKBPs ( Immunosuppression, Oncology) |
| Ratjadone | CRM1 |
| Rebeccamycin | Antitumor, Topoisomerase I And II |
| RES-701-1 | Antagonists Of The Type B Receptor Of Endothelin |
| Resistoflavine | Cytotoxic |
| Resistomycin | RNA Polymerase |
| Resourculin | |
| Reticulol | Topoisomerase |
| Reutericin | |
| Reutericyclin | Ionophore, Bacteriostatic |
| Reveromycin | Antiosteoclastic/Osteporosis, G1 Phase Cell Cycle Inhibitor, Isoleucyl-tRNA Synthetase |
| Rhamnose Tylactone | Bacterial Ribosome |
| Rhizopodin | Actin (Oncology) |
| Rhizoxin | Tubulin (Oncology) |
| Rhodanodin | |
| Rifampicin | Bacterial RNA Polymerase. |
| Rifaximin | Bacterial RNA Polymerase. |
| Rimocidin | Antifungal |
| Ristocetin | Antibacterial |
| Rk-1009 (Factumycin) | Protein Biosynthesis Inhibitor |
| Rk-682 | Inhibitor Of Protein Tyrosine Phosphatase |
| Roflamycoin | Antifungal |
| Rosamicin | Bacterial Ribosome |
| Rosamycin | Antibiotic (Bacterial Ribosome) |
| Roxaticin | Antifungal |
| Rp-35665 | |
| Rubiginone D2 | Antibiotic, Antitumour |
| Rubradirin | Ribosomal Polypeptide Biosynthesis Inhibitor |
| Rubrivinodin | |
| Ruminococcin A | |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| S-54832-A-I | |
| Saccharocarcin | Antimicrobial, GRP78 Transcription Inhibitor |
| Safracin | Antibiotic |
| Safracin B | Antitumor |
| Saframycin A | Rna Synthesis Inhibitor |
| SAL-2242 | |
| Salinilactam | Antifungal |
| Salinomycin | Coccidiostat, Ionophore Antibacterial |
| Salivaricin 9 | |
| Salivaricin A | |
| Sanglifehrin | Cyclophilins (Antiviral) |
| SapB | |
| SAPT, SAP-T | |
| Saxitoxin | Shellfish Toxin |
| Sch 38519 | Platelet Aggregation Inhibior |
| Sch 725674 | Antifungal |
| Sch-40832 | |
| Semduramycin | Anticoccidal |
| Septamycin | Ionophore, Anticoccidal Antibiotic |
| Sf2487 | Influenza |
| Sf2575 | Anticancer |
| Siamycin | Anti-HIV |
| Sibiromycin | Transcription Factor Inhibition |
| Simocyclinone D8 | Gyrase Inhibitor, Protein Kinase Inhibitor, Antibiotic |
| Sinefungin | Antifungal |
| Siomycin A | Forkhead Box M1(FoxM1) Inhibitor |
| Smb A | |
| Smb B | |
| Soetomycin | |
| Soraphen | Acetyl-Coa Carboxylase Inhibitor (ACC) |
| Spectinomycin | Antibacterial |
| Sphingonodin I | |
| Sphingonodin II | |
| Sphingopyxin II | |
| Spinosad | Insecticide |
| Spinosyn | Insecticidal, Nicotinic Acetylcholine Receptor Activators (NAChRs) |
| Spiramycin | Antibacterial, Bacterial Ribosome. Antibacterial, Antiprotozoal |
| Spirangein | |
| Spirangien | |
| Spirangien A | Antimitotic |
| Spliceostatin | Spliceosome |
| Sporaviridin | |
| Sporulation Killing Factor | |
| Spumigin A | Thrombin Inhibitor |
| Sr015-2005 | |
| Sro15-2005 | |
| Sro15-2212 | |
| SSV-2083 | Inhibition Of fsr Quorum Sensing In Enterococcus faecalis |
| Stachybotrylactam | Weakly Inhibits HIV-1 Protease |
| Stackepeptin | |
| Stambomycin | Anticancer |
| Staphylococcin C55 Alpha | |
| Staphylococcin C55 Beta | |
| Stauprimide | PKC, NME2 (PUF) |
| Staurosporine (Staurosporin) | OKC, Tyrosine Kinase, CDK2/Cyclin A, CDK4/Cyclin D, IKKa And IKKb (Oncology) |
| Steffimycin B | Preferentially Active Against ras Oncogene-Expressed Cell |
| Sterigmatocystin | Toxin |
| Stigmatellin | Electron Transport Chain Inhibitor |
| Streptide | |
| Streptin | |
| Streptococcin A-Ff22 | |
| Streptococcin A-M49 | |
| Streptocollin | |
| Streptolydigin | Inhibitor Of RNA Polymerase |
| Streptolysin S | Hemolytic |
| Streptomonomicin | |
| Streptomycin | Anti-Tubercular |
| Streptothricin | Antibacterial |
| Streptozotocin | Inhibition Of Beta-Cell O-GlcNAcase, Antitumour |
| Strevertene | Antifungal |
| Stylisin 1 | |
| Stylissamide A | |
| Sublancin 168 | Antimicrobial |
| Subtilin | |
| Subtilomycin | |
| Subtilosin | |
| Sulfomycin | |
| Sultriecin | PP2A |
| Sungsanpin | |
| Surfactin | Surfactant |
| Sviceucin | |
| Syanodin I | |
| Syringomycin | Surfactant, Pore Former |
| Syringopeptin | Antimicrobial |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Tallysomycin | Antitumor |
| Tan-1323 D | V-ATPase |
| Taromycin A | Antibiotic |
| Tautomycetin | PP1, PP2A (Oncology) |
| Tautomycin | PP1, PP2A |
| Tawicyclamide A | |
| Tawicyclamide B | |
| Teicoplanin | Antibacterial |
| Teixobactin | Cell Wall Synthesis Inhibition (Antibacterial) |
| Telomycin | Antimicrobial |
| Tenellin | Iron Chelator |
| Tenuecyclamide A | |
| Tetracenomycin C | Antitumor |
| Tetracycline | Antibacterial |
| Tetrocarcin | Bcl-2 Inhibitor, Antitumour |
| Tetrocarcin A | Bcl-2 Inhibitor, Antitumour |
| Tetromycin | Phosphatidylinositide-3'-Kinase/Akt Signalling Pathway |
| Tetromycin A | Phosphatidylinositide-3'-Kinase/Akt Signalling Pathway |
| Tetromycin C Aglycone Derivative | |
| Tetronasin | Ionophore |
| Tetronomycin | Antibiotic |
| Thailandamide | |
| Thaxtomin | Herbicide |
| Thermolide | Nematocidal |
| Thermophilin-1277 | |
| Thiazinotrienomycin A | Cytotoxic |
| Thiazomycin | |
| Thienamycin | Antibacterial |
| Thioactin | |
| Thiocillin | |
| Thiocoraline | DNA Replication Inhibitor, Antitumour |
| Thiofeed | |
| Thiomuracin A | EF-Tu Inhibitor |
| Thiopeptin | |
| Thioplabin G | |
| Thioplabin J | |
| Thiostrepton | Antibacterial (Prokaryotic 50S Ribosomal Subunit) |
| Thiostrepton A | |
| Thiostrepton A2 | |
| Thiotipin | |
| Thioviridamide | |
| Thioxamycin | |
| Thuggacin A | Antibiotic |
| Thurandacin A | |
| Thurandacin B | |
| Thuricin C | |
| Thuricin D | |
| Thurincin H | |
| Tirandamycin | Antibiotic, Antiuberculosis |
| Tirandamycin 3 | Antibiotic, Antiuberculosis |
| Tmc 135A | Antitumor |
| Tmc 135B | Antitumor |
| Tobramycin | Antibacterial |
| Tolypomycin Y | Antimycobacterial Antibiotic |
| Trichamide | |
| Trichostatin | HDAC Inhibitor (Oncology) |
| Triedimycin A | Antiviral |
| Triedimycin B | Antiviral |
| Trienomycin | Antitumour And Antibiotic (Oncology) |
| Trifolitoxin | |
| Trunkamide | Antitumor |
| T-Toxin | Phytotoxin |
| Tubelactomicin | Antibiotic - Tuberculosis |
| Tubulysin | Tubulin (Oncology) |
| Tubulysin B | Tubulin (Oncology) |
| Tunicamycin | Antibacterial |
| Tylactone | Antibiotic |
| Tylosin | Antibacterial (Ribosome) |
| Tyrocidine | Cell Membrane (Antibacterial) |
| Tyrocydine | |
| Uk86956 | Antiparasitic |
| Ulicyclamide | |
| Ulithiacyclamide | Cytotoxic |
| Undecylprodigiosin | Antibacterial |
| Unphenelfamycin | Antibiotic |
| Urdamycin A | Antiosteoclastic/Osteporosis, G1 Phase Cell Cycle Inhibitor, Isoleucyl-tRNA Synthetase |
| Urukthapelstatin A | |
| Ushkulide A | Immunosuppressant |
| Microbial Natural Products | Literature application and target / natural product mechanism of action |
| Vacidin A | Antibiotic |
| Val-Geninthiocin | |
| Validamycin | Antifungal |
| Valinomycin | Ionophore: Transport Of Potassium And As An Antibiotic |
| Vanchrobactin | Siderophore |
| Vancomycin | Antibiotic |
| Vancoresmycin | Antibiotic |
| Variacin | |
| Venezuelin | |
| Venturamide A | |
| Venturamide B | |
| Venturicidin (Aabomycin) | V-ATPase (Oncology) |
| Versipelostatin | GRP78 Pathway |
| Vibriobactin | Siderophore |
| Vicenistatin | Antibiotic |
| Vicibactin | Siderophore |
| Viomycin | Antibacterial (70S Ribosome) |
| Viranamycin A | Antibiotic |
| Virginiamycin M1 | Antibacterial |
| Virginiamycin S1 | Inhibit Ribosome Assembly (60S Ribosomal Protein L37) |
| Viridisamide | |
| Virustomycin | Oncology (V-ATPase) |
| Vm 54339 | Antibiotic |
| Wainunuamide | |
| Wewakazole | |
| X 14885A | Antibiotic |
| X-206 | Ion Transporter |
| Xantholysin A | Antimicrobial |
| Xanthomonin | |
| Yersiniabactin | Toxin |
| Ym 216391 | |
| Ym-266183 | |
| Ym-266184 | |
| Yokonolide | Auxin-Dependent Aux/IAA Degradation |
| Zearalenone | Agonist Of The GPER (GPR30) |
| Zorbamycin | Oncology |
| Zucinodin | |
| Zwittermicin | Antibacterial (Membrane And Transcription) |