drugs

Isomerase has supported many biotech and pharma companies with drug discovery, development and manufacturing. Examples have included the following:

  • Developing and running screening cascades - to discover novel bioengineered drugs in a range of therapeutic areas with partners following supply of a Target Product Profile (TPP)
  • Generating and helping scale recombinant lower cost fermentation processes - to generate drug candidates following initial drug discovery and/or clinical development with a candidate made by synthetic chemistry
  • Discovering and supporting manufacturing of biocatalytic processes - to replace or support synthetic chemistry routes to candidate drugs
  • Accessing microbial natural products - for biological testing following selection by partner using in silico selection or following literature reports of activity
  • ADC payloads - generation of novel payloads or for use with Antibody Drug Conjugates (ADCs) and support with manufacturing
  • Drug development support - with early-stage analytical method development and characterisation studies (solubility, stability, microsome stability, metabolic fate, internal standard procurement)
  • Early-stage formulation studies - (solubility, stability) to enable in vivo assessment

Isomerase is adept at accessing difficult to access chemical space, whether that is a genetically encoded small molecule (e.g. natural product or peptide) or identifying and producing a key biocatalyst to enable small molecule compound supply.

We’d be delighted to discuss your project and explore opportunities to collaborate - contact us

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