Integrated Platforms for Enzyme Discovery, Biocatalysis and Microbial Strain Engineering
Isomerase is a biotechnology R&D partner that helps companies turn biological innovation into commercial products and processes. Its work runs through two platforms: IsoZym®, for enzyme discovery, engineering and biocatalysis development, and IsoStream®, for microbial strain engineering, metabolic engineering and natural product development, serving pharma, biotech, agritech, food, ingredients, consumer products and sustainable manufacturing.
Over the past decade Isomerase has combined platform technologies with expertise in microbiology, synthetic biology, enzyme engineering, fermentation, analytical chemistry and process development to solve complex technical challenges, whether you are developing an enzyme-enabled manufacturing process or building a microbial production platform for a high-value molecule.
Which platform fits your project?
| IsoZym® | IsoStream® |
|---|---|
| Enzyme discovery & engineering | Microbial strain engineering |
| Biocatalysis development | Natural product development |
| Protein expression | Fermentation & scale-up |
| Reaction optimisation | Pathway engineering |
| Fermentation & scale-up | Strain improvement |
IsoZym®
Enzyme Discovery, Engineering and Biocatalysis Development
IsoZym® is Isomerase's integrated platform for enzyme discovery, protein engineering and biocatalytic process development. It supports organisations seeking novel, improved or scalable enzymes for industrial biotechnology, chemical manufacturing, pharmaceuticals, food ingredients, agritech and sustainable production.
From target identification and assay development through to enzyme discovery, ML-guided engineering, microbial expression, fermentation and technology transfer, IsoZym® provides a structured route from enzyme challenge to commercial solution.
Typical applications include:
- Discovery of novel enzymes for difficult reactions
- Zero-shot enzyme engineering to improve activity, selectivity or stability (EvoSelect®)
- Freedom-to-operate replacement enzymes
- A range of recombinant production hosts (IsoChassis®)
- Biocatalytic process development and optimisation
- Enzyme expression, production and scale-up
- Enzyme cascade development and reaction engineering
Discover how IsoZym® can help accelerate your enzyme innovation programme.
IsoStream®
Microbial Strain Engineering, Metabolic Engineering and Natural Product Development
IsoStream® is Isomerase's platform for microbial production of natural products, speciality chemicals and bio-based molecules. It brings together strain engineering, pathway design, fermentation development, downstream processing and scale-up expertise to help partners transform promising biology into commercially relevant manufacturing processes.
The platform supports projects ranging from early-stage natural product discovery and biosynthetic pathway development through to strain optimisation, bioprocess development and CDMO technology transfer.
Typical applications include:
- Natural product discovery and development
- Metabolic engineering and pathway optimisation to generate metabolites and small molecules, including rare sugars, biomolecules, flavours and fragrances
- Microbial strain development and optimisation
- Genome mining and sourcing of bioactive compounds from a proprietary collection of over 20,000 microbial strains and complementary external collections
- Fermentation and bioprocess scale-up
- Bio-based production of speciality chemicals
- Technology transfer and manufacturing readiness
Discover how IsoStream® can help unlock the potential of microbial production systems.
Why Partner with Isomerase?
Our multidisciplinary team has delivered hundreds of research and development projects across biotechnology, pharmaceuticals, industrial biotechnology, food, ingredients and agritech. We combine deep technical expertise with strong project management, clear milestones and commercially focused decision-making.
Unlike many technology providers, we work with flexible project structures and do not typically depend on downstream royalties. Our goal is to help partners develop robust, scalable solutions while maintaining freedom to commercialise their products.
Ready to discuss your project?
Contact our team to explore how IsoZym® or IsoStream® can support your next innovation programme.